Fong-Sian Lin Assistant Research Fellow

Education

Doctor of Engineering and System Science, National Tsing Hua University
Master of Chemistry, National Cheng Kung University
Bachelor of Applied Chemistry, National Chi Nan University

Research expertise

Skin bio-printing is a promising technology to produce human artificial skin for applications. The artificial skin can be used for safety test of medicines and cosmetics, which can replace the animal tests and expect to generate more consistent and reproducible results. Moreover, bio-printed skin can create complex cell composition and spatial distribution that can mimic human skin color, function and reaction. We anticipate producing the skin by bioprinting with patient’s skin cells that can generate large area skin tissue for skin autograft surgery. Using bioprinting technique with minimal patient’s tissue will reduce harvested area at donor site and discomfort of patients with large wound size.

Drug-loaded nanoparticles are studied for their synthesis, characterization and the drug releasing efficiency. The relationship between drug-loaded nanoparticles, cell proliferation and tissue regeneration is also investigated. Materials including polymer, metal and ceramic can be used to produce nanoparticle. By using hydrophilic or hydrophobic chemical linkers, varied medicines can be loaded into or onto nanoparticles for different application. Drug releasing profile can be controlled by chemical and/or physical interaction between medicine and nanoparticle. To design the burst or controlled release of varied drugs from nanoparticle can perform a suitable concentration for tissue regeneration.

Paper

  1. Chen CH, Lin FS, Liao WN, Liang SL, Chen MH, Chen YW, Lin WY, Hsu MH, Wang MY, Peir JJ, Chou FI, Chen CY, Chen SY, Huang SC, Yang MH, Hueng DY, Hwu Y, Yang CS, Chen JK. Establishment of a Trimodality Analytical Platform for Tracing, Imaging and Quantification of Gold Nanoparticles in Animals by Radiotracer Techniques. Anal Chem 2015;87:601. (IF: 6.785, Ranking: 7/86=8.1%) (co-first author)
  2. Liu CP, Lin FS, Chien CT, Tseng SY, Luo CW, Chen CH, Chen JK, Tseng FG, Hwu Y, Lo LW, Yang CS, Lin SY. In-situ Formation and Assembly of Gold Nanoparticles by Gum Arabic as Efficient Photothermal Agent for Killing Cancer Cells. Macromol Biosci 2013;13:1314. (IF: 3.416, Ranking: 17/89=19.1%) (co-first author)
  3. Lin FS, Chien CTe, Chiu WC, Lin SY, Tseng FG, Hwu Y, Yang CS. Chemical auxiliary-free polymerization yielding non-linear PEG for protein-resistant application. RSC Adv 2012;2:7174. (IF: 3.119, Ranking: 73/177=41.2%)
  4. Lin SY, Lin FS, Chen MK, Tsai LR, Jao YC, Lin HY, Wang CL, Hwu YK, Yang CS. One-pot synthesis of linear-like and photoluminescent polyethylenimines for intracellular imaging and siRNA delivery. Chem Commun 2010;46:5554. (IF: 5.996, Ranking: 34/177=19.2%)
  5. Chen SH, Hsu JL, Lin FS. Fluorescein as a versatile tag for enhanced selectivity in analyzing cysteine-containing proteins/peptides using mass spectrometry. Anal Chem 2008;80:5251. (IF: 6.785, Ranking: 7/86=8.1%)

Research team

Ming-You Shie Associate Research Fellow China Medical University, School of Dentistry Assistant Professor

Education

Research expertise

Biomaterials Developments / Cell Culture / Animal Study